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. Author manuscript; available in PMC: 2015 Feb 1.
Published in final edited form as: Biochim Biophys Acta. 2013 May 7;1840(2):10.1016/j.bbagen.2013.04.040. doi: 10.1016/j.bbagen.2013.04.040

Figure 2.

Figure 2

Anatomy of the phagocyte NADPH oxidase.

The membrane component of the phagocyte NADPH oxidase, flavocytochrome b558, is a heterodimeric heme-containing flavoprotein comprised of NOX2 (aka gp91phox) and p22phox located in unstimulated neutrophils in the plasma membrane and membranes of secretory vesicles and specific granulesIn stimulated neutrophils, cytoplasmic components are recruited to the membrane (see text), and NADPH binds to NOX2 and shuttles electrons to FAD and across the membrane via the two inequivalent hemes (magenta dodecahedrons) linked between transmembrane helices in NOX2. Consequently, oxygen undergoes single electron reduction to form O2·.