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. Author manuscript; available in PMC: 2015 Feb 1.
Published in final edited form as: Biochim Biophys Acta. 2013 May 7;1840(2):10.1016/j.bbagen.2013.04.040. doi: 10.1016/j.bbagen.2013.04.040

Figure 3.

Figure 3

Composition of activated NOX protein family members in membranes.

Individual NOX proteins vary in their requirements for associated p22phox, cytosolic cofactors, and calcium-binding EF hands. In addition, DUOX1 and 2 have an extracellular peroxidase-like (PRX-like) domain and associated transmembrane helix not present in other NOX protein family members. Whereas the phagocyte oxidase (NOX2) and NOX1, 3, and 5 produce O2· extracellularly, only H2O2 is recovered extracellularly from NOX4, DUOX1 or DUOX [see text for details].