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. Author manuscript; available in PMC: 2015 Jan 1.
Published in final edited form as: Biochim Biophys Acta. 2013 Apr 6;1844(1 0 0):10.1016/j.bbapap.2013.03.023. doi: 10.1016/j.bbapap.2013.03.023

Fig. 1.

Fig. 1

Qualitative clinical observation indicates an iterated loss of lung function (blue) in CF patients, which generically occurs in a non-monotonic fashion characterized by acute pulmonary exacerbations (APEs). Even with aggressive treatment, the patient typically does not recover fully from an APE, and the result is a negative trend (red dotted line) in lung function over time and a resultant reduced life expectancy.