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. Author manuscript; available in PMC: 2014 Sep 1.
Published in final edited form as: Neurotoxicology. 2013 Jun 10;38:67–73. doi: 10.1016/j.neuro.2013.06.002

Fig. 2.

Fig. 2

Mn induced cell cytotoxicity in SH-SY5Y cells which was potentiated by iron depletion. To assess effect of iron depletion on Mn-induced cell cytotoxicity, cells were treated with (solid circle) or without (open circle) 50 μM DFO for 24 h, followed by treatment with indicated concentrations (0, 10, 50, 100, 500, and 1000 μM) of MnCl2 for another 48 h. Cell viability was measured using MTT assay. Data represent mean ± SEM as percent of values observed in untreated cells (% of control, n = 3–4 samples/treatment). *P < 0.05 vs. Mn-untreated control, #P < 0.05 for control vs. DFO treatment group; two-way ANOVA.