Fig. 1.

Ctr1C can function as a copper importer in fly brain nervous system. Specifically, over-expression of Ctr1C in the fly nervous system using a pan-neuronal elav-Gal4 driver caused copper-dependent lethality when fly larvae were raised on normal food at 25°C, but could be rescued by supplying a concentration gradient of BCS (A). Such flies could survive to adulthood when they were raised at a lower temperature (18 °C), but showed rough eyes (B). The “relative to male” is the calculation of the percentage of the number of eclosed female flies to male flies in each group. Gray column (control) represents progeny of ♂w¹¹¹⁸×♀ elav-Gal4 crosses. Blue column represents progeny of ♂UAS-Ctr1C×♀ elav-Gal4 crosses.