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. Author manuscript; available in PMC: 2014 Nov 1.
Published in final edited form as: Neurobiol Aging. 2013 Jul 2;34(11):2604–2612. doi: 10.1016/j.neurobiolaging.2013.05.029

Fig. 2.

Fig. 2

Reduced Ctr1C expression can ameliorate the climbing and longevity defects of Aβ42 flies. (A) Aβ42 expression in fly brains (elav-Gal4>UAS-Aβ42) induced a climbing deficit as compared with control elav-Gal flies. Knocking down Ctr1C by RNAi (elav-Gal4>UAS-Aβ42/UAS-Ctr1C-RNAi) could significantly increase the climbing ability of Aβ42 flies. Two-way ANOVA, **p<0.01, ***p<0.001 (in comparison with elav-Gal4>UAS-Aβ42 flies). n=4 independent experiments. (B) In the absence of Aβ42 expression, no significant locomotor deficits were found among elav-Gal4 and elav-Gal4>UAS-Ctr1C-RNAi flies. n=4 independent experiments. (C–D) Ctr1C knockdown significantly lengthened the lifespan of Aβ42 flies. The percentage survivorship was plotted against age (C). Ctr1C RNAi significantly prolonged the life span of Aβ42 flies, with a 32.4% extension in median lifespan over that of Aβ42 flies at 25 °C (p<0.0001, C and D). Reported P values are from Mantel-Cox log-rank statistical analysis.