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. Author manuscript; available in PMC: 2014 Nov 1.
Published in final edited form as: Neurobiol Aging. 2013 Jul 2;34(11):2604–2612. doi: 10.1016/j.neurobiolaging.2013.05.029

Fig. 7.

Fig. 7

Kocking down Ctr1B and over-expressing DmATP7 can ameliorate the climbing and longevity defects of Aβ42 flies. (A) Ctr1B knockdown and DmATP7 over-expression significantly lengthened the lifespan of Aβ42 flies, with a 17.9% and a 33.3% extension in median lifespan over that of Aβ42 flies at 25 °C (p<0.0001), respectively. Reported P values are from Mantel-Cox log-rank statistical analysis. The percentage survivorship was plotted against age. n=4 independent experiments. (B) The climbing deficit of Aβ42 expression flies was rescued through knocking down Ctr1B by RNAi or over-expressing DmATP7. Two-way ANOVA, ***p<0.001 (in comparison with elav-Gal4>UAS-Aβ42 flies). n=4 independent experiments.