Supplementary Table 1.

Multivariate Cox Regression Analysis of Association of Lkb1, p21 and Clinicopathological Parameters with Overall Survival

	Hazard ratio	95% CI	P value
Tumor stage (T3 vs T2)	2.20	1.20−4.41	.014
Tumor size (>30 mm vs ≤30 mm)	1.65	1.09−2.51	.02
Resection margin status (positive vs negative)	1.97	1.16−3.4	.012
Tumor grade (high vs low)	2.54	1.60−4.11	<.001
Vascular invasion (yes vs no)	1.18	0.81−1.72	.38
p21 (Histoscore ≤40 vs >40)	1.09	0.65−1.84	.71
Lkb1 (Histoscore ≤100 vs >100)	1.87	1.09−3.22	.023

CI, confidence interval.