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. 2012 Dec 10;39(5):562–571. doi: 10.1111/nan.12007

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Neuropathology and Applied Neurobiology © 2013 British Neuropathological Society

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Immunohistochemistry of sporadic amyotrophic lateral sclerosis (SALS) case with p.K54E ANG mutation. Images show p62 (a–d), TDP-43 (e–g), FUS (h), angiogenin (i), H&E (j), CD68 (k) and α2 actinin (l) showing: neuronal (a, b, d, e and g) and glial (c and f) cytoplasmic inclusions in the spinal cord; neuronal cytoplasmic inclusions in the motor cortex (d and g); normal, predominantly nuclear labelling of FUS in the spinal cord (h), granular cytoplasmic staining in a motor neurone with the appearance of lipofuscin (i); Bunina bodies (arrowheads; j); a microglial reaction that is most marked in the lateral descending tract of the spinal cord and least marked in the dorsal columns (k); normal labelling of Z-disc in skeletal muscle by α2 actinin (l). Scale: a–i and l, bar = 20 μm; j, bar = 20 μm; k, bar = 1 mm.