Table 1.
Active metabolites of psychotropic drugs with antidepressants properties.
| Parent drug | Active metabolite | Reference |
|---|---|---|
| ANTIDEPRESSANTS | ||
| Amitriptyline | Nortriptyline* | Owens et al. (5) |
| Nortriptyline | 10-OH-Nortriptyline | Nordin and Bertilsson (6) |
| Imipramine | Desimipramine* | Owens et al. (5) |
| Desimipramine | Desmethyl desimipramine | Deupree et al. (7) |
| Trimipramine | Desmethyl trimipramine, 2-OH-Trimipramine, Trimipramine N-oxyde | Haenisch et al. (8) |
| Clomipramine | Desmethyl clomipramine# | Tekes et al. (2) |
| Doxepin | Desmethyl doxepin | Tekes et al. (2) |
| Mianserine | Desmethyl mianserine | Kang et al. (9) |
| Mirtazapine | Desmethyl mirtazapine | Sitzen and Zivkov (4), Zivkov et al. (72) |
| Maprotiline | Desmethyl maprotiline | Wille et al. (1) |
| Trazodone | m-Chlorophenylpiperazine | Wille et al. (1) |
| Citalopram | Desmethyl citalopram, Didesmethyl citalopram | Tatsumi et al. (12), Popik (13), Milne and Goa (14), Caccia (73) |
| Escitalopram | Desmethyl citalopram, Didesmethyl citalopram | Tatsumi et al. (12) |
| Fluoxetine | Desmethyl fluoxetine | Owens et al. (5), Wong et al. (16) |
| Fluvoxamine | Fluvoxamine acid | Benfield and Ward (15), Caccia (73) |
| Sertraline | Desmethyl sertraline | Fuller et al. (11), Caccia (73) |
| venlafaxine | N-Desmetil venlafaxine* | Owens et al. (5), Muth et al. (20), Caccia (73) |
| Atomoxetine | 4-Hydroxy atomoxetine | Tekes et al. (2) |
| ANTIPSYCHOTICS | ||
| Aripiprazole | m-Chlorophenylpiperazine | Caccia (33) |
| Risperidone | 9-OH-Risperidone *# | Yang and Liang (38) |
| Quetiapine | Norquetitapine | Jensen et al. (49) |
*Marketed as individual drug; #suspected activity.