Table 2.
Pharmacodynamic properties of quetiapina, risperidone, and their active metabolites (norquetiapine and paliperidone).
| Receptors | Quetiapine* | Norquetiapine* | Risperidone** | 9-OH-risperidone (paliperidone)** |
|---|---|---|---|---|
| D2 | 245 | 196 | 4.9 | 9.4 |
| 5-HT2A | 100 | 48 | 0.17 | 1.9 |
| 5-HT2C | 2502 | 107 | 12 | 48 |
| 5-HT1A | 432 | 45 | 427 | 640 |
| 5-HT7 | 307 | 76 | – | – |
| H1 | 11 | 3.5 | 5.2 | 5.6 |
| Alpha-1 | 22 | 144 | 5 | 2.5 |
| Alpha-2 | 3630 | 237 | 151 | 4.7 |
| NET | >10000 | 58 | – | – |
Data are in Ki (nanomoles).
NET (norepinephrine transporter).
*Jensen et al. (49).
**PDPS Ki database: http://pdsp.med.unc.edu/pdsp.php).