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. 2013 Sep 11;33(37):14825–14839. doi: 10.1523/JNEUROSCI.1611-13.2013

Figure 3.

Figure 3.

The effect of Df(16)A on the density of cortical inhibitory interneurons. A, Left, Schematic representation of probe locations for quantifying density of inhibitory neurons labeled with a PV antibody (red) in the prelimbic area of mPFC of 8-week-old WT and Df(16)A+/− mice. Right, PV-labeled cells in mPFC of WT and Df(16)A+/− mice. The relative density of PV-labeled cells across seven bins from pia to white matter at the mPFC is shown. B, Left, Schematic representation of probe locations for quantifying density of inhibitory neurons labeled with a PV antibody (red) in the prelimbic area of mPFC of 8-week-old WT and Dgcr8+/− mice. Right, PV-labeled cells in mPFC of WT and Dgcr8+/− mice. The relative density of PV-labeled cells across seven bins from pia to white matter at the mPFC is shown. C, Left, Schematic representation of probe locations for quantifying density of inhibitory neurons labeled with a CB antibody (red) in the mPFC of 8-week-old WT and Df(16)A+/− mice. Right, CB-labeled cells in mPFC of WT and Df(16)A+/− mice. The relative density of CB-labeled cells across seven bins from pia to white matter at the mPFC is shown. D, Left, Schematic representation of probe locations for quantifying density of inhibitory neurons labeled with a CB antibody (red) in the mPFC of 8-week-old WT and Dgcr8+/− mice. Right, CB-labeled cells in mPFC of WT and Dgcr8+/− mice. The relative density of CB-labeled cells across seven bins from pia to white matter at the mPFC is shown. Data are shown as mean ± SEM. *p < 0.05. Scale bars, 100 μm.