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. Author manuscript; available in PMC: 2013 Sep 12.
Published in final edited form as: Sci Transl Med. 2013 Jun 19;5(190):190ra81. doi: 10.1126/scitranslmed.3006276

Fig. 8. Ag+ potentiates bactericidal antibiotic activity in vitro against bacterial persister cells.

Fig. 8

(A) Kill curves for persister E. coli cells treated with various concentrations of AgNO3. (B) Changes in HPF fluorescence after 3 h of administering AgNO3 at various concentrations. (p<0.05 and 0.001 for 30 and 60 μM, respectively) (C) Changes in PI fluorescence after 3 h of administering different concentrations of AgNO3. (p<0.05 and 0.001 for 30 and 60 μM, respectively) (D, E) Kill curves for E. coli persister cells treated with 30 μM AgNO3, 5 μg/mL gentamicin (Gent), 3 μg/mL ofloxacin (Oflox), 10 μg/mL ampicillin (Amp), and combinations of AgNO3 with the respective antibiotics. Error bars represent mean ± SEM for at least 6 biological replicates. *** indicates a p-value of <0.001 and ** indicates a p-value of <0.05 as determined by a student t-test, indicating a significant difference from the untreated control, unless otherwise indicated.