Table 2.
Micro-computed tomography analysis of vertebrae and femora of the WT and the pd male mice
| WT males | pd males | |||
|---|---|---|---|---|
|
|
|
|||
| Normal diet | Low Ca | Normal diet | Low Ca | |
|
|
|
|
|
|
| L5 Vert | ||||
| BV/TV (%) | 27.9±1.5 | 17.4±1.1† | 26.3±1.4* | 16.2±1.2*,† |
| TbTh (mm) | 50.3±1.9 | 48.4±0.8† | 50.9±1.3 | 48.2±1.0† |
| TbN (1/mm) | 5.99±0.30 | 4.08±0.26† | 5.58±0.36* | 4.23±0.18† |
| TbSp (mm) | 157±9 | 241±17† | 171±14* | 233±13† |
| Conn | 278.2±30.2 | 140.0±17.6† | 264.2±35.2 | 137.3±22.6† |
| SMI | 1.04±0.12 | 1.60±0.17† | 1.26±0.16* | 1.88±0.167*,† |
| MinD | 919±37 | 720±24† | 896±37 | 726±36† |
| Distal femur | ||||
| BV/TV (%) | 17.01±4.07 | 8.68±0.96† | 18.34±4.10 | 8.98±0.99† |
| TbTh (mm) | 55.8±8.3 | 49.0±1.1† | 53.3±4.8 | 48.1±1.6† |
| TbN (1/mm) | 4.73±0.43 | 3.20±0.33† | 4.67±0.66 | 3.45±0.28† |
| TbSp (mm) | 208±24 | 301±13† | 213±33 | 291±24† |
| Conn | 154.9±28.8 | 67.8±10.6† | 176.1±44.1 | 75.5±15.3† |
| SMI | 2.41±0.019 | 2.79±0.11† | 2.18±0.38 | 2.78±0.11† |
| MinD | 934±49 | 703±31† | 908±78 | 753±33*,† |
| Mid-shaft femur | ||||
| TA | 1.86±0.14 | 1.58±0.07† | 1.88±0.21 | 1.60±0.06† |
| BA | 0.736±0.088 | 0.333±0.049† | 0.758±0.111 | 0.386±0.082† |
| MA | 1.129±0.096 | 1.250±0.043† | 1.118±0.120 | 1.213±0.052† |
| BA/TA (%) | 39.4±3.2 | 21.0±2.3† | 40.3±2.7 | 24.0±4.4† |
| Cort Thick | 164.5±18.9 | 74.8±10.8† | 164.4±15.4 | 85.1±15.5† |
| Cort MinD | 1402±21 | 1276±30† | 1380±13* | 1283±25† |
|
|
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WT, wild-type; pd, phosphorylation-deficient PTH1R; Ca, calcium.
Values are mean±S.D. (n=6 from each group);
*
P<0.05 versus WT;
†
P<0.05 low calcium diet versus normal.
BV/TV, bone volume/total volume; TbTh, trabecular thickness; TbN, trabecular number; MinD, mineral density, Conn, connectivity; SMI, structure model index; TA, total area; BA, bone area; MA, marrow area; Cort Thick, cortical thickness; Cort MinD, cortical mineral density.