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. 2013 Jul 30;32(17):2362–2376. doi: 10.1038/emboj.2013.157

Figure 7.

Figure 7

MCUb acts as a dominant negative on MCU. (A) [Ca2+]mt measurements in control, MCU- and MCUb-silenced intact HeLa cells challenged with 100 μM histamine. (B) [Ca2+]mt measurements in intact HeLa cells overexpressing MCU or MCUb. (C) [Ca2+]mt measurements in control, MCU-, MCUb- and MCU/MCUb-silenced permeabilized HeLa cells perfused with 2 μM buffered [Ca2+]. (D) [Ca2+]mt measurements in intact HeLa cells overexpressing MCU, MCUR251W,E256V, and MCUD260N,E263Q. Descriptive statistics can be found in Supplementary Table S1. *P<0.05, **P<0.001.