Table 3.

Hazard ratios for end-stage renal disease in chronic kidney disease populations according to eGFR and albuminuria clinical categories by the presence or absence of diabetes

	Individuals with diabetes					Individuals without diabetes
	ACR <30, PCR <50, or dipstick negative or trace	ACR 30–299, PCR 50–499, or dipstick 1+	ACR 300–999, PCR 500–1499, or dipstick 2+	ACR ≥1000, PCR ≥1500, or dipstick ≥3+	Overall	ACR <30, PCR <50, or dipstick negative or trace	ACR 30–299, PCR 50–499, or dipstick 1+	ACR 300–999, PCR 500–1499, or dipstick 2+	ACR ≥1000, PCR ≥1500, or dipstick ≥3+	Overall
eGFR ≥75	1·47; 0·63–3·41	2·47^*^†; 1·29–4·73	3·43^*^†; 1·58–7·47	4·42^*; 2·20–8·86	0·81^†; 0·21–3·17	0·54; 0·07–4·05	0·68^†; 0·38–1·20	0·74^†; 0·33–1·63	1·59; 0·54–4·68	0·46^*^†; 0·28–0·75
eGFR 45–74	Reference	1·76^*; 1·05–2·95	2·84^*; 1·11–7·27	8·01^*; 3·62–17·7	Reference	Reference	1·69^*; 1·23–2·32	2·85^*; 1·22–6·66	3·93^*; 2·78–5·55	Reference
eGFR 30–44	2·11^*^†; 1·26–3·51	3·35^*; 2·07–5·41	5·71^*; 3·57–9·13	8·56^*; 5·27–13·9	1·86^*; 1·58–2·19	1·42^†; 0·85–2·37	3·01^*; 2·23–4·06	4·20^*; 3·04–5·81	6·76^*; 4·90–9·31	1·87^*; 1·48–2·38
eGFR 15–29	2·98^*; 1·68–5·28	8·25^*; 5·19–13·1	23·7^*; 8·09–69·3	33·7^*; 13·8–82·4	5·23^*; 3·81–7·17	6·15^*; 3·17–12·0	7·94^*; 5·93–10·6	11·9^*; 7·17–19·8	28·9^*; 10·5–79·6	7·64^*; 4·99–11·7
eGFR <15	1·74; 0·23–13·1	34·7^*; 4·21–285	122^*; 4·64–3229	35·7^*; 21·5–59·4	9·46^*; 5·52–16·2	3·97^*; 1·58–10·0	16·0^*; 11·5–22·4	22·7^*; 16·1–32·0	31·8^*; 18·9–53·4	18·3^*; 10·9–30·6
Overall	Reference	1·60; 0·85–3·02	3·55^*; 2·89–4·36	6·79^*; 4·36–10·6	··	Reference	1·86^*; 1·32–2·62	2·70^*; 1·78–4·08	5·56^*; 3·44–9·00	··

Data are hazard ratio; 95% CI. eGFR is mL/min per 1·73 m². ACR and PCR are mg/g. Reference categories were eGFR 45–74 mL/min per 1·73 m² and ACR <30 mg/g, PCR <50 mg/g, or a dipstick test for albuminuria ≤trace.

p<0·05 relative to the reference category.

^†

p<0·05 for interaction with hypertensive status for the corresponding category.