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. Author manuscript; available in PMC: 2014 Sep 1.
Published in final edited form as: Trends Biochem Sci. 2013 Jul 16;38(9):467–475. doi: 10.1016/j.tibs.2013.06.009

Fig. 2. Rpd3(L) is recruited twice to the HO promoter during the cell cycle.

Fig. 2

The Rpd3(L) histone deacetylase is first recruited to HO URS1 by Ash1, at about 25 min after release from G2/M arrest. Later in the cell cycle, Rpd3(L) is recruited to the URS2 region of the HO promoter by the SBF DNA-binding factors and the intermediary proteins Whi5 and Stb1. There is no evidence that Rpd3(L) shifts its position along the promoter or is handed from one factor to another. It is more likely that Rpd3(L) binding at URS1 ends when Ash1 is degraded, and that a new molecule of Rpd3(L) is recruited by SBF/Whi5/Stb1. The HO promoter is labeled as described in Fig 1.