Official websites use .gov
A
.gov website belongs to an official
government organization in the United States.
Secure .gov websites use HTTPS
A lock (
) or https:// means you've safely
connected to the .gov website. Share sensitive
information only on official, secure websites.
The fold-increase of luciferase activity was determined for B12-K34R-GLP-1 (1) and K34R-GLP-1(7–36) after HEK-GLP-1R cells were transfected with a RIP1-CRE-Luc reporter and exposed to 1, K34R-GLP-1 or free B12 for 4 h. B12-K34R-GLP-1 (1) produced a concentration-dependent response with an EC50 value of 4.4 nm, while K34R-GLP-1 exhibited an EC50 value of 4.1 nm.
