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. Author manuscript; available in PMC: 2013 Sep 12.
Published in final edited form as: Nat Immunol. 2012 Feb 12;13(3):223–228. doi: 10.1038/ni.2236

Figure 4.

Figure 4

Vpx rescues the infection of an HIV-1 that encodes a mutant RT with a reduced affinity for dNTP. (a) MDM were pre-incubated with Vpx-containing or control VLP and then infected with wild-type or RT V148I mutant HIV-GFP at an MOI of 1. Four days post-infection, GFP+ cells were quantified by flow cytometry. (b) The efficiency of infection in the presence and absence of Vpx is displayed as the ratio of mutant/wild-type virus. A ratio of 1 indicates equivalent infection efficiency of wild-type and RT V148I mutant HIV-1.