Table 2.

Cellular localization, activity, and biological function of sirtuins 1–7 according to [63].

Sirtuin	Localization	Activity	Biological function
Sirt1	Nucleus/cytosol	Deacetylase	Cell survival/metabolism
Sirt2	Cytosol	Deacetylase	Cell cycle
Sirt3	Mitochondria	Deacetylase	Thermogenesis/metabolism
Sirt4	Mitochondria	ADP-ribosyltransferase	Insulin secretion/metabolism
Sirt5	Mitochondria	Deacetylase	Unknown
Sirt6	Nucleus	ADP-ribosyltransferase	DNA repair
Sirt7	Nucleolus	Unknown	rDNA transcription

ADP: adenosine diphosphate; rDNA: ribosomal desoxyribonucleic acid; Sirt: sirtuin.