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Regulation of transcription by HIF-1 during ambient and hypoxic condition. HIF: hypoxia-inducible factor; HPH: HIF-1 prolyl-hydroxylases; VHL: Von Hippel-Lindau; E3UL: E3 ubiquitin ligase; HRE; hypoxia-response element; GLUT; glucose transporter: LDH: lactate dehydrogenase; PDK, pyruvate dehydrogenase kinase (see text for details).
