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Suppression of mitochondrial respiration by HIF-1α in hypoxic environment. HIF: hypoxia-inducible factor; HRE: hypoxia-response element: GLUT: glucose transporter; LDH: Lactate dehydrogenase; PDH: pyruvate dehydrogenase; PDK: pyruvate dehydrogenase kinase; TCA: tricarboxylic acid; ETC: electron transport chain; ROS: reactive oxygen species (see text for details).
