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Crosstalk between hypoxia and notch signaling, and regulation of stem cell proliferative gene expression. HIF: hypoxia-inducible factor; NEC: notch extracellular domain; NIC: notch intracellular domain; RBP: recombination-signal binding protein. (Modified from Gustafsson et al., (2005) [34] and Sainson and Harris (2006) [136]; see text for details).
