Table 2.
The intervention and the outcome measures of the individual studies included in this study.
| Study ID | The regimens of intervention | Time | Assessment of outcomes | |
|---|---|---|---|---|
| Trials group | Control group | |||
| Shen et al., 1999 [5] | Compound Danshen injection (16 mL) and Huangqi injection (20 mL) were, respectively, added into 5%–10% glucose solution (250 mL), intravenously, qd. | Aspartic potassium, vitamin C, and B6 were added into 5% glucose, intravenously. | 28 d | Total efficacy rate; serum indices of liver fibrosis and liver function. |
| Chen et al., 2000 [6] | Compound Danshen injection (20 mL) and Huangqi injection (20 mL) were, respectively, added into 5% glucose solution, intravenously, qd. | Used hepatoprotective treatment (mainly energy mixture and vitamins), qd. | 90 d | Serum indices of liver fibrosis. |
| Cai et al., 2001 [7] | Compound Danshen injection (20 mL) and Huangqi injection (20 mL) were, respectively, added into 5% glucose solution, intravenously, qd. | Used silymarin orally, tid. | 90 d | Total efficacy rate; serum indices of liver function. |
| Zhou, 2002 [8] | Compound Danshen injection (20 mL) and Huangqi injection (10 mL) were together added into 250 mL of 5% glucose solution, intravenously, qd. | Vitamin C, vitamin B6, inosine, and potassium chloride injection were added into 5% glucose solution intravenously, qd. | 75 d | Total efficacy rate; serum indices of liver function. |
| Liu et al., 2002 [9] | Danshen injection (30 mL) and Huangqi injection (20 mL) were, respectively, added into 250 mL of 5% glucose solution, intravenously, qd. | Added ganlixin into the 5% glucose, intravenously. | 90 d | Serum indices of liver function. |
| Chen et al., 2003 [10] | Danshen injection (30 mL) and Huangqi injection (16 mL) were, respectively, added into 250 mL of 5% glucose solution, intravenously, qd. | 30 mL of ganlixin injection, intravenously, qd. | 28 d | Serum indices of liver fibrosis and liver function. |
| Cai, 2004 [11] | Compound Danshen injection (30 mL) and Huangqi injection (10 mL) were, respectively, added into 250 mL of 5% glucose solution, intravenously, qd. | Energy mixture, branched-chain amino acids, albumin, and vitamin were used. | 75 d | Serum indices of liver fibrosis and liver function. |
| Wu et al., 2006 [12] | Danshen injection (25 mL) and Huangqi injection (25 mL) were, respectively, added into 250 mL of 5% glucose solution, intravenously, qd. | Routine western medicine treatment. | 84 d | Serum indices of liver function; liver hemodynamics. |
| Yi and Li, 2007 [13] | Danshen injection (20 mL) and Huangqi injection (20 mL) were, respectively, added into 250 mL of 5% glucose solution, intravenously, qd. | Used silymarin orally, 3 times a day. | 90 d | Total efficacy rate; serum indices of liver function. |
| Pen and Wang, 2010 [14] | Danshen injection (30 mL) and Huangqi injection (30 mL) were, respectively, added into 250 mL of 5% glucose solution, intravenously, qd. | Hepatoprotective therapy using nosine and vitamins. | 30 d | Serum indices of liver fibrosis and liver function. |
| Liu et al., 2010 [15] | Danshen injection (30 mL) and Huangqi injection (30 mL) were, respectively, added into 250 mL of 10% glucose solution, intravenously, qd. | Hepatoprotective and supportive therapy and lamivudine (100 mg) orally, qd. | 90 d | Serum indices of liver fibrosis and liver function; HBeAg; HBV-DNA. |
The regimens in the trials group included the drugs used in the control group. Compound Danshen injection: mainly contains Danshen and an added constituent (Lignum Dalbergiae Odoriferae).