. Author manuscript; available in PMC: 2013 Sep 12.

Published in final edited form as: Nat Rev Microbiol. 2007 Jul;5(7):540–553. doi: 10.1038/nrmicro1662

Table 2. Response to wild-type Shigella flexneri 2a.

Challenge	Adverse clinical outcomes			IgA anti-O-antigen ASC
	Diarrhoea	Dysentery	Fever	% Responders	Geometric mean^*
	Challenge no. 1	12/14 (86%)	10/14 (71%)	10/14 (71%)	100%	71
Challenge no. 2	11/12 (92%)	10/12 (83%)	10/12 (83%)	92%	239

This Table shows the consistency of the clinical and immunological response in North American adult volunteers following challenge with 10³ colony-forming units (CFU) of wild-type Shigella flexneri 2a strain 2457T administered with NaHCO₃ buffer.

Per 10⁶ PBMC. ASC, antibody-secreting cells; PBMC, peripheral blood mononuclear cells.