. Author manuscript; available in PMC: 2013 Sep 12.

Published in final edited form as: Nat Rev Microbiol. 2007 Jul;5(7):540–553. doi: 10.1038/nrmicro1662

Table 3. The role of the ShET1 and ShET2 enterotoxins.

Strain	Adverse clinical outcomes						IgA anti-O-antigen ASC
	Diarrhoea		Dysentery		Fever		% Responders	Geometric Mean^*
	10⁸	10⁹	10⁸	10⁹	10⁸	10⁹	10⁹	N/A
ΔguaBA (CVD 1204)	3/7 (43%)	4/7 (57%)	0/7	0/7	0/7	4/7	100%	445
ΔguaBA, Δset, Δsen, (CVD 1208)	0/7	0/7	0/7	0/7	0/7	1/7	86%	62

This Table shows the consistency of the clinical and immunological response in North American adult volunteers to ingestion of 10⁸ or 10⁹ colony-forming units (CFU) of two deletion mutants of wild-type S. flexneri 2a strain 2457T with NaHCO₃ buffer.

Per 10⁶ PBMC. ASC, antibody-secreting cells; PBMC, peripheral blood mononulcear cells; ShET, Shigella enterotoxin.