Table 2.
Characteristics of each case-control replication study group
| Characteristic | COPDGene | ECLIPSE | NETT/NAS | GenKOLs | ||||
|---|---|---|---|---|---|---|---|---|
| Cases | Controls | Cases | Controls | Cases | Controls | Cases | Controls | |
| Number of participants | 499 | 501 | 1764 | 178 | 373 | 435 | 863 | 808 |
| Age (mean ± SD), years | 64.77 (8.12) |
60.2 (8.66) |
63.63 (7.10) |
57.48 (9.44) |
67.47 (5.78) |
69.8 (7.49) |
65.53 (10.03) |
55.62 (9.71) |
| Smoking history (mean ± SD), pack-yearsa | 54.76 (26.69) |
38.87 (21.07) |
50.29 (27.42) |
32.11 (24.84) |
66.43 (30.68) |
40.66 (27.85) |
31.98 (18.46) |
19.66 (13.58) |
| FEV1 (mean ± SD), % predictedb | 48.73 (18.41) |
97.98 (11.32) |
47.63 (15.62) |
107.83 (13.56) |
28.12 (7.38) |
99.97 (13.2) |
50.63 (17.44) |
94.91 (9.24) |
| Sex (% Male) | 49.5% | 50.1% | 67.0% | 57.9% | 63.8% | 100% | 60.1% | 50.1% |
a)
Number packs of cigarettes smoked per day × number of years of smoking.
b)
Lung function measured as forced expiratory volume in 1 second (FEV1).