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Nitric oxide (NO) generation in aorta. Representative electrochemical detection tracing of NO concentration in isolated aortas from the senescence marker protein-30 (SMP30) knockout (KO) and wild type (WT) mice in an organ chamber. NO concentration is directly proportional to the current (pA) by a free-radical analyzer (Apollo 4000). ACh (1 μM)-stimulated NO release was attenuated in SMP30 KO mice vs. WT mice (p<0.01). ACh indicates acetylcholine administration.
