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Ach-induced coronary artery spasm. Intra-aortic sinus administration of ACh (2 μg) to the SMP30 KO mice induced transient ST-T segment elevation and reciprocal ST-T segment depression in electrocardiogram (A). In the WT mice, ACh-induced ST-T segment change did not appear (B). Before, after 1, 2, and 5 min; before, after 1-, 2-, and 5-min intra-aortic sinus administration of ACh, respectively.
