Figure 2.

Reduced expression of chemokine and chemokine receptors in knockout eyes compared with the wild type. (A) Heat map of 20 chemokine/receptor genes differentially expressed between wild type, SR-A^−/−, MARCO^−/−, and DKO before, and after laser injury. Before laser injury, the expression profile is similar between wild-type and knockout eyes. After laser injury, wild-type laser had higher chemokine/receptor gene expression compared with knockout eyes. Red indicates an upregulation, black indicates no change, and green indicates downregulation. (B) When examining the chemokine/receptor expression after laser to before laser in the animal groups, the wild-type ratio had the highest number of upregulated genes and the least number of unchanged genes compared with knockout eyes.