Figure 7.

(A) Example hERG current (I_hERG) traces in vehicle control (0.02% DMSO, black line), after 2 minutes perfusion of vehicle control solution (grey line) and in the presence of 3 μM quinidine (light grey line). The lower panel shows the voltage protocol. (B) Representative I_hERG records in vehicle control (black line) and in the presence of 10 μM SPHINX (grey line) elicited by the protocol shown in the lower panel. (C) Mean data (± SEM) showing the continuous time-plot of effect of 10 μM SPHINX (solid circle, n = 5 cells) and 10 μM SRPIN340 (open circle, n = 5 cells) on I_tail. The solid square plot shows the effect of 0.02% DMSO on I_tail as vehicle control and 3 μM quinidine as positive control (n = 4 cells). For each cell, the hERG tail current amplitude was normalized to the maximal I_tail observed in control. (D) Bar chart showing the mean fractional I_hERG tail inhibitory levels produced by 10 μM SRPIN340, 10 μM SPHINX, vehicle control, and 3 μM quinidine.