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. Author manuscript; available in PMC: 2013 Sep 12.
Published in final edited form as: Dev Biol. 2011 Dec 1;362(2):295–308. doi: 10.1016/j.ydbio.2011.11.012

Figure 1. All major components of the Notch signaling pathway are present inNematostella vectensis.

Figure 1

A, NvNotch is similar in organization and residue identity to those found in Bilaterian animals. B, Several DSL domain-containing sequences were isolated from N. vectensis. The Nematostella Delta contains one DSL domain, EGF repeats and a predicted transmembrane domain. Two additional DSL domain-containing sequences are unusual in the presence of multiple DSL domains. One of these sequences was found to contain a transmembrane domain. C, Four Hes genes (NvHes1-4) and three Hes-like (NvHl1-3) genes are present in N. vectensis. Conserved domains of the NvHes and NvHl genes are the bHLH domain (b and HLH), the orange domain (OR) and the C-terminal WRPW peptide. NvHes1 lacks a WRPW domain but maintains an orange and HLH domain. Positions of domains are indicated by numbers which refer to residues of the predicted protein.