Table 1.
Patient Characteristics
| Patient | Age (years) | Gender | Subtype | ISS Stage | PS | No. prior regimens | Previous transplant | β2-mg (g/dl) | Albumin (g/dl) | Se M-protein (mg/dl)* | U M-protein (g/24 h)* | Karyotype (FISH) |
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 1 | 41 | F | IgG.κ | I | 1 | 3 | Yes | 2.5 | 3.6 | 3880 | - | Normal |
| 2 | 55 | M | IgG.κ | II | 2 | 2 | No | 4.4 | 2.0 | 6650 | 525 | Normal |
| 3 | 65 | M | IgG. κ | II | 1 | 1 | No | 4.6 | 3.7 | 2059 | - | +15 |
| 4 | 65 | M | IgA. κ | II | 1 | 1 | No | 3.4 | 2.9 | 3750 | 526 | Hyperdiploid |
| 5 | 55 | F | IgA. κ | II | 0 | 2 | Yes | 2.7 | 3.6 | 2910 | - | 13q- |
| 6 | 63 | F | IgG. κ | III | 1 | 2 | Yes | 7.9 | 4.1 | 2636 | 1195 | Complex, 13q- |
| 7 | 61 | F | IgG. κ | II | 0 | 3 | Yes | 4.7 | 3.4 | 1920 | - | Hyperdiploid |
| 8 | 58 | F | IgG. κ | I | 0 | 2 | No | 3.2 | 3.7 | 1469 | - | Hyperdiploid |
| 9 | 71 | M | IgG. κ | I | 0 | 2 | No | 3.2 | 4.0 | 1138 | - | Hyperdiploid |
| 10 | 62 | M | IgA. κ | I | 0 | 5 | Yes | 3.2 | 4.5 | 128 | 3681 | Hyperdiploid |
| 11 | 75 | F | IgG. κ | II | 1 | 1 | No | 3.5 | 3.8 | 3119 | - | Normal |
| 12 | 74 | M | free λ | I | 0 | 3 | Yes | 3.0 | 3.8 | - | 536 | Normal |
| 13 | 73 | M | free κ | II | 0 | 1 | No | 5.1 | 3.4 | - | 2732 | 13q- |
| 14 | 57 | M | IgG. λ | II | 1 | 1 | No | 2.9 | 2.4 | 4210 | 242 | t(11;14) |
| 15 | 58 | F | IgG. λ | II | 2 | 3 | No | 4.2 | 3.3 | 1826 | - | Normal |
| 16 | 58 | F | IgG. λ | II | 1 | 2 | yes | 4.2 | 2.1 | 1369 | - | Normal |
ISS, International Staging System; PS, performance score on the ECOG scale; Se, serum; U, urine;
*
(−) denotes absent serum or urine M-protein; FISH, karyotype assessed by interphase fluorescent in-situ hybridization.