Skip to main content
. Author manuscript; available in PMC: 2014 Sep 1.
Published in final edited form as: Pharm Res. 2013 Jul 30;30(9):2199–2208. doi: 10.1007/s11095-013-1101-9

Figure 3. Carapin, santonin and isokobusone activated human and mouse CAR.

Figure 3

(A and B) HEK293 cells were co-transfected with hCAR (hCAR1) or hCAR3 (A) and mCAR or mCAR3 (B), together with the tk-PBRE-Luc reporter gene. Transfected cells were treated with the vehicle or the indicated compounds (10 μM each) for 24 h before luciferase assay. CITCO (1 μM) and TCPOBOP (250 nM) were included as the positive control ligands for hCAR and mCAR, respectively. Results are shown as fold induction over vehicle control and represent the averages from triplicate assays. *, P < 0.05, vs vehicle control of each receptor or its mutant variant.