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. Author manuscript; available in PMC: 2014 Sep 1.
Published in final edited form as: Pharm Res. 2013 Jul 30;30(9):2199–2208. doi: 10.1007/s11095-013-1101-9

Figure 4. Carapin, santonin and isokobusone induced the expression of CAR target gene CYP2B in human and mouse primary hepatocytes.

Figure 4

Human and mouse primary hepatocytes were treated vehicle DMSO), CITCO (1 μM), TCPOBOP (250 nM), carapin, santonin, or isokobusone (10 μM each) for 24 h. CYP2B6 and Cyp2b10 mRNA expression was measured by real-time PCR analysis. Data were expressed as fold change over the control, normalized to GAPDH expression. *, P < 0.05, vs the vehicle controls of each genotype.