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. Author manuscript; available in PMC: 2014 Sep 1.
Published in final edited form as: Pharm Res. 2013 Jul 30;30(9):2199–2208. doi: 10.1007/s11095-013-1101-9

Figure 6. Carapin, santonin and isokobusone inhibited the LPS-responsive expression of pro-inflammatory genes in human primary hepatocytes.

Figure 6

(A and B) Human primary hepatocytes were pre-treated with vehicle, RIF, carapin, santonin or isokobusone (10 μM each) for 24 h before the addition of 20 μg/ml LPS for 6 h. Total RNA was isolated and the expression of iNOS (A) and MCP-1 (B) was determined by real-time PCR. Data were normalized to cyclophilin expression and expressed as fold change over controls. *, P < 0.05, vs LPS alone treatment groups. N = 3 for each group.