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. Author manuscript; available in PMC: 2013 Sep 12.
Published in final edited form as: Biochim Biophys Acta. 2011 Feb 2;1812(5):613–618. doi: 10.1016/j.bbadis.2011.01.016

Fig. 3.

Fig. 3

Infusion of ethanol or propanol decreased hepatic SAM concentration. Isolated rat liver was infused with ethanol (EtOH, 20 mM) or propanol (Prop, 20 mM) for 60 min, and S-adenosylmethionine (SAM) content was measured in liver lobules. Ethanol or propanol infusion resulted in a significant decrease of the liver SAM. The effect of ethanol was markedly attenuated by co-infusion of 4-methylpyrazole (4-MP, 4 mM), an inhibitor of alcohol dehydrogenase, and pyruvate (Pyr, 10 mM). Groups that do not share a common letter are significantly different (p<0.05).