Figure 5. Upregulation of glucose utilization in awake rats exceeds that in anesthetized rats.

Data are plotted from studies summarized in Table 4 of (Dienel, 2012b). Values are pairs of rates obtained in the same brain structure during rest and activation, and they represent different stimuli (sensory, chemical, or electrical) to different brain regions. Values that fall above the line of identity (solid line) indicate upregulation of CMR_glc during activation compared with rest. Individual points cannot be directly compared with each other because the responses vary with brain region and stimulus paradigm. Nevertheless, increases in CMR_glc in awake subjects are greater and have a wider range compared with anesthetized subjects that are outlined by the dashed rectangle.