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. 2013 Aug 14;143(10):1565–1572. doi: 10.3945/jn.113.176834

FIGURE 1.

FIGURE 1

Effect of MTP inhibition on cell-associated tocopherols and basal tocopherol secretion in Caco-2 monolayers. Monolayers were preincubated for 3 h with BMS201038 or with the equivalent volume of DMSO vehicle. Mixed micelles providing 10 μmol/L α-, γ-, and δ-TOH were added apically. (A) Cell-associated tocopherols were determined after 24 h. (B) Basal tocopherol and cholesterol secretion into DMEM was determined after 24 h. (C) Secretion efficiency after 24 h, where secretion efficiency = mass secreted relative to the total mass taken up by the cells (cell plus secreted tocopherol). Results are expressed as means ± SDs, n = 3. *P < 0.001 vs. control; x, P < 0.05 vs. control; labeled means in the same treatment without a common letter differ: a–c, P < 0.01; d–f, P < 0.05; BMS, BMS201038; chol, unesterified cholesterol; MTP, microsomal triglyceride transfer protein; TOH, tocopherol.