Table 1.
4 weeks |
8 weeks |
|||
---|---|---|---|---|
WTD (n = 10) | WTD + XN (n = 13) | WTD (n = 8) | WTD + XN (n = 9) | |
TC (mmol/L) | 23.8 ± 1 | 16.3 ± 1*** | 26.5 ± 0.8 | 20.3 ± 1.1*** |
FC (mmol/L) | 7.4 ± 0.4 | 5.4 ± 0.4** | 8.3 ± 0.3 | 6.5 ± 0.4** |
CE (mmol/L) | 16.2 ± 0.8 | 10.9 ± 0.6*** | 18.2 ± 0.6 | 13.8 ± 0.7*** |
TG (mmol/L) | 0.8 ± 0.1 | 0.8 ± 0.1 | 1.2 ± 0.1 | 1.5 ± 0.2 |
| ||||
XN plasma concentrations | ||||
XN (nmol/L) | Fasted plasma n.d. |
Fed plasma 61 |
ApoE−/− mice were fed WTD ± XN for 8 weeks. Plasma was isolated from overnight fasted mice after 4 and 8 weeks, respectively, and TG, TC, and FC concentrations were measured enzymatically. CE concentrations were calculated as CE = TC − FC.
XN plasma concentrations were measured in pooled samples from WTD + XN-fed ApoE−/− mice (n = 4) after 4 weeks of feeding.
Data are expressed as mean values ±SD.
p ≤ 0.01
p ≤ 0.001.
n.d., not detected.