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. 2013 Sep 12;8(9):e75069. doi: 10.1371/journal.pone.0075069

Figure 6. Anti-metastatic activity of sWRE and Withaferin A in an allograft breast cancer mouse model.

Figure 6

(A and B) Mean tumor volume in mice treated with 1, 4, 8mg/kg of (A) sWRE or (B) Withaferin A (WFA) (* p<0.05 compared to control). (C) Representative images of the primary tumor in sWRE or WFA treated mice. (D and E) Bar graph showing the mean number of metastatic lung nodules in (D) sWRE or (E) WFA-treated mice (* p<0.05 compared to control). (F) Representative H&E staining images showing the histology of metastatic nodules in mouse lung; two examples shown. (G) Representative images of lung metastatic nodules (black arrows) in mice treated with vehicle control (9% EtOH) or sWRE or WFA at 8mg/kg.