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. 1971 Mar;21(3):387–393. doi: 10.1128/am.21.3.387-393.1971

Interferon-Inducing Characteristics of MM Virus

D J Giron 1, P T Allen 1, F F Pindak 1, J P Schmidt 1
PMCID: PMC377189  PMID: 4324191

Abstract

Interferon induction by MM virus in mice and in L cells was studied. In mice the virus readily induced interferon. The time of appearance was dose-dependent. A large virus dose induced interferon by 4 hr, whereas a small dose resulted in interferon production which paralleled virus replication 24 hr after infection. In L cells the interferon-inducing capacity of the virus was rapidly destroyed by ultraviolet light irradiation. Heating (56 C) of the virus, on the other hand, greatly increased its ability to induce interferon. Interferon production could also be increased by prior treatment of the cells with homologous interferon (priming). The increase in interferon production after priming was dependent on the concentration of interferon used for priming, the length of interferon treatment, and the multiplicity of infection. It is suggested that MM virus might be useful for the further study of the mechanisms involved in the production and action of interferon.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

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