Figure 4. AD transgenic mouse models had increased locomotor activity in the open field.

Both APP+PS1 and Tg4510 mice displayed greater total distance travelled in the open field, compared to nontransgenic control mice, regardless of the diet. Locomotor activity was assessed during a single 15min trial in the open field. Data are presented as mean ± SEM. **p<0.005 and ***p<0.0001.