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Spatial memory was assessed by the 2-day radial arm water maze (RAWM). (A) Both APP+PS1 and Tg4510 (tau) mice made more errors on the 2-day RAWM compared to Ntg control mice, regardless of the diet. (B) APP+PS1 and Tg4510 mice consistently made more entries into the wrong arms, suggesting that neither were able to learn a new platform location on the reversal trial. Data are presented as mean ± SEM. **p<0.01 and ***p<0.0001.
