Figure 7. Ad-199T antitumor activity on HCC xenograft.
CD1 nude mice (n=6) bearing Hep3B xenografts were treated intra-tumorally either with PBS or with Ad-199T (5x108 I.U. each treatment, for a total of six). (A) A tumor growth curve was built by measuring the size of tumors every two days. The results shown a significant difference between the PBS-treated group and the Ad-199T-treated one (p=0.001), confirming the antitumor activity of Ad-199T virus. (B) Kaplan-Meier survival plot showed a median survival of 24 days for untreated animals and 45 days for Ad-199T treated animals, thus indicating a longer survival time in animals treated with the oncolytic adenovirus. This difference was highly significant according to the log-rank test (p <0.0001).