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. 2013 Sep 15;24(18):2885–2893. doi: 10.1091/mbc.E12-11-0798

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© 2013 Applewhite et al. This article is distributed by The American Society for Cell Biology under license from the author(s). Two months after publication it is available to the public under an Attribution–Noncommercial–Share Alike 3.0 Unported Creative Commons License (http://creativecommons.org/licenses/by-nc-sa/3.0).

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FIGURE 6: — A model for the autoinhibition of Shot's actin-microtubule cross-linking. Shot is targeted to the growing ends of microtubules through EB1 and is maintained in an autoinhibited conformation through and intramolecular interaction between Shot's ABD and EF-hand/GAS2 domains. On relief of this autoinhibition, Shot's conformation is “open,” allowing it to bind to the sides of microtubules through its GAS2 domain and to actin through its ABD, thereby cross-linking the two networks.