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. 2013 Sep 15;24(18):3000–3009. doi: 10.1091/mbc.E13-05-0275

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© 2013 Stec et al. This article is distributed by The American Society for Cell Biology under license from the author(s). Two months after publication it is available to the public under an Attribution–Noncommercial–Share Alike 3.0 Unported Creative Commons License (http://creativecommons.org/licenses/by-nc-sa/3.0).

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FIGURE 4: — The N-terminal and SH2 domain of SOCS36E are required for binding to Dome. (A) Coimmunoprecipitation of SOCS36E-FLAG following pull down of Dome and Hop is shown in the presence and absence of exogenous ligand. Cells were also treated with the indicated dsRNAs targeting LacZ, Hop, or Dome. (B and C) Levels of tyrosine phosphorylation detected following immunoprecipitation of Dome (B) and Hop (C) are shown under stimulated and unstimulated conditions. (D) Coimmunoprecipitation of FLAG-tagged SOCS36E constructs following Dome-HA pull down. While each of the indicated SOCS36E constructs (which migrate at different molecular weights) is expressed (right), only full-length and SOCS36EΔSB coimmunoprecipitate with the receptor (left).