Table 2. Effect of 4HPR or ERK inhibitor (UO126) treatment on cytokine secretion in FXR1-WT & KO macrophage cell lines.
| A | Medium | 4HPR | p valuea | UO126b | p valuea | |
| n = 8 | n = 8 | (4HPR vs Medium) | n = 4 | (UO126 vs Medium) | ||
| IL-6 (pg/ml) | FXR1-WT | 0.0±0.0 | 0.0±0.0 | = 0.721 | 0.0±0.0 | = 0.808 |
| FXR1-KO | 0.0±0.0 | 0.0±0.0 | = 0.721 | 0.0±0.0 | = 0.808 | |
| CCL2 (pg/ml) | FXR1-WT | 64.9±5.2 | 32.6±4.5 | <0.001 | 24.5±8.4 | = 0.002 |
| FXR1-KO | 214.3±24.5 | 170.6±19.8 | = 0.187 | 194.5±29.3 | = 0.637 | |
| CCL5 (pg/ml) | FXR1-WT | 1.0±0.7 | 4.8±1.0 | = 0.136 | 2.5±1.4 | = 0.808 |
| FXR1-KO | 6.5±1.9 | 8.0±1.4 | = 0.521 | 2.5±1.4 | = 0.203 |
a
The p values were calculated using unpaired t-test.
b
ERK inhibitor UO126 used at 5 µM.