Table 3. Distribution frequency of ICAM-1 genotypes in 561 healthy controls and 595 oral cancer patients.
| Variable | Controls (N = 561) n (%) | Patients (N = 595) n (%) | OR (95% CI) | AOR (95% CI) |
| rs3093030 | ||||
| CC | 365 (65.1%) | 384 (64.5%) | 1.00 | 1.00 |
| CT | 179 (31.9%) | 183 (30.8%) | 0.972 (0.756–1.249) | 1.126 (0.784–1.617) |
| TT | 17 (3.0%) | 28 (4.7%) | 1.566 (0.843–2.909) | 1.149 (0.468–2.822) |
| CT+TT | 196 (34.9%) | 211 (35.5%) | 1.023 (0.804–1.303) | 1.129 (0.797–1.599) |
| rs5491 | ||||
| AA | 514 (91.6%) | 537 (90.3%) | 1.00 | 1.00 |
| AT | 47 (8.4%) | 55 (9.2%) | 1.120 (0.745–1.684) | 1.523 (0.826–2.809) |
| TT | 0 (0%) | 3 (0.5%) | — | — |
| AT+TT | 47 (8.4%) | 58 (9.7%) | 1.181 (0.789–1.768) | 1.618 (0.887–2.953) |
| rs281432 | ||||
| CC | 324 (57.8%) | 332 (55.8%) | 1.00 | 1.00 |
| CG | 200 (35.7%) | 218 (36.6%) | 1.064 (0.832–1.360) | 1.211 (0.849–1.728) |
| GG | 37 (6.6%) | 45 (7.6%) | 1.187 (0.748–1.882) | 1.199 (0.604–2.379) |
| CG+GG | 237 (42.2%) | 263 (44.2%) | 1.083 (0.858–1.367) | 1.209 (0.863–1.696) |
| rs5498 | ||||
| AA | 350 (62.4%) | 329 (55.3%) | 1.00 | 1.00 |
| AG | 182 (32.4%) | 220 (37.0%) | 1.286 (1.004–1.647) * | 1.377 (1.006–1.968) * |
| GG | 29 (5.2%) | 46 (7.7%) | 1.687 (1.035–2.750) * | 1.202 (1.029–4.712) * |
| AG+GG | 211 (37.6%) | 266 (44.7%) | 1.341 (1.060–1.697) * | 1.465 (1.041–2.063) * |
The odds ratios (ORs) and with their 95% confidence intervals (CIs) were estimated by logistic regression models. The adjusted odds ratios (AORs) with their 95% confidence intervals (CIs) were estimated by multiple logistic regression models after controlling for age, gender, betel nut chewing, tobacco and alcohol consumption.
*
P value<0.05 as statistically significant.