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. 2013 Sep 12;8(9):e72940. doi: 10.1371/journal.pone.0072940

Table 6. Clinical status and ICAM-1 genotypic frequencies in 595 oral cancer patients.

Variable rs3093030 rs5491 rs281432 rs5498
CC (N = 384) CT+TT (N = 211) p value AA (N = 537) AT+TT (N = 58) p value CC (N = 332) CG+GG (N = 263) p value AA (N = 329) AG+GG (N = 266) p value
Clinical Stage
Stage I/II 168 (43.8%) 93 (44.1%) 0.939 226 (42.1%) 35 (60.3%) 0.008 * 131 (39.5%) 130 (49.4%) 0.015 * 136 (41.3%) 125 (47.0%) 0.167
Stage III/IV 216 (56.2%) 118 (55.9%) 311 (57.9%) 23 (39.7%) 201 (60.5%) 133 (50.6%) 193 (58.7%) 141 (53.0%)
Tumor size
≤T2 239 (62.2%) 124 (58.8%) 0.406 322 (60.0%) 41 (70.7%) 0.112 193 (58.1%) 170 (64.6%) 0.106 195 (59.3%) 168 (63.2%) 0.334
>T2 145 (37.8%) 87 (41.2%) 215 (40.0%) 17 (29.3%) 139 (41.9%) 93 (35.4%) 134 (40.7%) 98 (36.8%)
Lymph node metastasis
No 242 (63.0%) 137 (64.9%) 0.643 337 (62.8%) 42 (72.4%) 0.146 208 (62.7%) 171 (65.0%) 0.551 206 (62.6%) 173 (65.0%) 0.541
Yes 142 (37.0%) 74 (35.1%) 200 (37.2%) 16 (27.6%) 124 (37.3%) 92 (35.0%) 123 (37.4%) 93 (35.0%)
Distant metastasis
No 378 (98.7%) 209 (98.5%) 0.533 529 (98.5%) 58 (100.0%) 0.349 325 (97.9%) 262 (99.6%) 0.069 322 (97.9%) 35 (99.6%) 0.065
Yes 6 (1.6%) 2 (0.9%) 8 (1.5%) 0 (0%) 7 (2.1%) 1 (0.4%) 7 (2.1%) 1 (0.4%)

T2: tumor size >2 cm in the greatest dimension.

*

P value<0.05 as statistically significant.